Depression Research

At the Roper St. Francis Research and Innovation Center, we are dedicated to ongoing research studies in search of new treatments and better understanding of depression and its symptoms.

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Participate in depression research

We understand depression and mood disorders, and the struggles that the symptoms bring to the patient and their loved ones. We value our research volunteers, as they truly become a part of our research family. There is hope in knowing that research participation can help in identifying the most effective remedies and therapies for patients suffering from treatment-resistant depression.


Volunteers are needed!

Depression and mood disorder research can only move forward if people are willing to volunteer for clinical trials and studies. Before any drug or therapy regimen can be used in clinical practice, it must be rigorously tested to find out whether it is safe and effective in humans.

Volunteers of all genders and races, age 18-80 are currently needed for study participation. This includes individuals with a diagnosis or complaints of depressive symptoms, receiving treatment(s) targeting mood symptoms and in need of further evaluation of their symptoms and treatment strategy.


What are the benefits of volunteering for a depression research study?

Participants in a research study have access to treatments that are being investigated for their potential to effectively minimize the presence of depressive symptoms and maximize the impact of proper anti-depressant usage and other therapy routines. Additionally, our team is able to provide participants with support and training in how to manage depression related symptoms.


What should you expect in a standard depression assessment?

The assessment involves proven measures used to evaluate complaints of depressive symptoms, other comorbid factors and treatment and response, as well as establishes a research diagnosis for either MDD and/or treatment-resistant MDD (TRD), if present. The testing is conducted in a quiet, relaxed interview room with one of our research study coordinators. Overall the depression assessment should take approximately 1.5-2 hours.


After the depression assessment

Once the depression assessment is complete, the research team will review your evaluation in its entirety as well as your medical records (once received). This information is kept strictly confidential. Dr. Olga Mintzer will be the final reviewer of the information and will make a research diagnosis for purposes of evaluating/recommending a research study you may qualify for. At any given time, we have a number of enrolling depression research studies, each with its own set of inclusion criteria (e.g. age parameters and/or excluded medical conditions). Therefore, the depression assessment and medical records help us determine a study that would be the best match for you. This process may take a few weeks once your depression assessment has been completed.

Your primary care doctor will then receive a report of all scores, a description of the rating scales used in the assessment, a summary of the currently enrolling depression trials, as well as notes regarding which study you may be eligible for participation. In some instances, there may not be a study that you qualify for. However, we will keep your information on file and recommend you contact us periodically to check on new studies you may qualify for (the depression assessment will not need to be repeated). If in fact you do qualify for a study, a member of our team will contact you to explain the study and schedule a time for you to review the study's informed consent and/or have a final screen complete a screening visit for the study. All of our studies are voluntary, so at any time you may discontinue the process based on your discretion.

To get started, contact our office at (843) 724-2302 to speak to a clinical coordinator.

Research questionnaire

We need volunteers like you to help us better understand what motivates an individual to participate in a depression research study. If you have a moment, complete a simple questionnaire that can provide our team with valuable information to help improve how our clinical trials are conducted.

Complete questionnaire
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